This year the iRNA got a concentration of abstracts on various aspects of RNA modifications (check out the schedule here). Indeed, epitranscriptomics is a 🔥 topic with many fundamental questions accompanied by both experimental and computational challenges. First, we organized a session to accommodate for the related talks. This then led to the following 💡: If we are already at ISMB and focusing on this topic, why don’t we invite some leading experts to weigh in on these “fundamental questions accompanied by both experimental and computational challenges”?? So we went ahead, made a few 📞 sent a few 🕊 (OK, fine, we just sent emails, it just doesn’t sound as cool), and got a terrific lineup of RNA modifications experts to answer your questions😃! See below who is on the panel and if you are @ ISMB 2021 (and you should be!) plan to join us July 29th (the panel start at 14:20 UTC but check out the talks before that too!) to learn what questions/problems may be the ones you want to go after next!
Research: Over 170 chemical modifications can be added to RNA post-transcriptionally, serving as a platform for diversifying the genetic code. Many of these modifications are highly conserved and implicated in human disease. By combining experimental with computational approaches, the Schwartz lab is interested in understanding who, what, where, when, how and perhaps most importantly – why.
Dr. Martinez will be opening her new lab at Stanford University (congrats !😃🎉)
The Martinez lab will investigate the molecular mechanisms and functions of pre-mRNA modifications in mRNA processing and how their regulation contributes to development and human diseases. Using high throughput genomics, molecular and cell biological approaches we will interrogate the role of pre-mRNA modifications in regulating gene expression.
Dr. Ke’s lab focuses on the molecular and regulatory mechanisms of N6-methyladenosine (m6A) mRNA modification which is the most abundant internal mRNA modification, critical for many developmental processes and involved in human diseases including cancer and neurological diseases. The lab implements interdisciplinary approaches to address biological mechanisms including state of art deep learning, innovative biochemistry, systematic genomic CRISPR KO screening, and human iPSC/brain organelle differentiation. The lab is a member of the Jackson Laboratory Cancer Center which is an NCI-designated cancer center and supported by grants from NIH NIGMS, American Cancer Society, and the Jackson Laboratory Cancer Center.